Anticancer and probiotic activities of Lacticaseibacillus paracasei isolated from traditionally fermented pickles

Koçpinar E. F., Alan Y., ERTAŞ M., Savci A.

Journal of the Science of Food and Agriculture, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/jsfa.70012
  • Dergi Adı: Journal of the Science of Food and Agriculture
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Periodicals Index Online, Aerospace Database, Agricultural & Environmental Science Database, Analytical Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Communication Abstracts, Food Science & Technology Abstracts, INSPEC, Metadex, Pollution Abstracts, Veterinary Science Database, DIALNET, Civil Engineering Abstracts
  • Anahtar Kelimeler: Anticancer, Antioxidant, Bacterial adhesion, Lacticaseibacillus paracasei, Postbiotics
  • Hakkari Üniversitesi Adresli: Evet

Özet

Background: Probiotics are living organisms and play a pivotal role in the natural treatment of gastrointestinal disorders including diarrhea, constipation, lactose intolerance and some bowel cancers. Beneficial effects are mostly attributed to postbiotic metabolites produced by bacteria, and the unique biological characteristics may vary depending on their species and source. The present study focused on identifying unique Lacticaseibacillus paracasei strains with unique probiotic and anticancer effects originating from fermented pickles. Results: Bacterial strains isolated from naturally fermented pickles were identified by 16S rRNA sequence analysis. Their probiotic properties were determined in simulated gastrointestinal environments created by pancreatin and pepsin. In addition, their adhesion capacities on L-929, HT-29 and Caco-2 cell lines were tested and then the cytotoxic effects of postbiotic metabolites and bacterial extracts obtained from bacterial isolates on cell lines were tested to determine their anticancer activities. In the overall results, isolates were found to be acceptable probiotics and to have anticancer activity. Conclusion: In addition to the acceptable activities of all strains, by elucidating their interaction mechanisms and evaluating their probiotic, functional and antiproliferative effects under in vivo conditions, especially LP001 and LP002 could be true sources of probiotics with anticancer effects in food and healthcare fields. © 2025 Society of Chemical Industry.