The phenolic profile and biological activities of common Scorzonera species from Eastern Anatolia

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Babakr S. H., Emre M. E., MÜKEMRE M., Dalar A.

International Journal of Secondary Metabolite, vol.9, no.4, pp.538-550, 2022 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.21448/ijsm.1084743
  • Journal Name: International Journal of Secondary Metabolite
  • Journal Indexes: Scopus, CAB Abstracts, Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.538-550
  • Keywords: Antioxidant, Enzyme inhibitory, Pancreatic lipase activity, Phenolics, Scorzonera
  • Hakkari University Affiliated: Yes


The present study focused on chemical composition and base therapeutic potential of common three Scorzonera species (Scorzonera mollis M.Bieb. subsp. mollis, Scorzonera papposa DC. and Scorzonera semicana DC), which have been utilized as food and medicine by local people of Eastern Anatolia for a long time. Comparative analytical studies were performed on ethanol-based extracts and traditional preparations (infusions) through chromatographic (HPLC-MS/MS) and reagent-based antioxidant and enzyme inhibitory assays. Results revealed that leaf extracts were rich in phenolics, particularly hydroxycinnamic acids that were confirmed by HPLC-MS/MS, chlorogenic acids and luteolin were the major phytochemical compounds of extracts. With regards to biological activities findings, it was determined that ethanol-based extracts showed better antioxidant activities and effectively suppressed the activities of α-glucosidase. In addition, both of the extracts were found as strong suppressive agents of pancreatic lipase activity so Scorzonera species were rich sources of bioactive compounds that able to deactivate reactive oxygen species and free radicals and as well as suppress the activities of α-glucosidase and pancreatic lipase. Finally, obtained findings reveal base data of Scorzonera species for researches that focused on novel candidates of nutraceuticals and biotherapeutics.