Effects of Gundelia tournefortii L. On biochemical parameters, antioxidant activities and DNA damage in a rat model of experimental obesity Efeitos de Gundelia tournefortii L. Em parâmetros bioquímicos, atividades antioxidantes e danos ao DNA em um modelo de obesidade experimental de rato

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Bati B., Çelik İ., Vuran N. E., Turan A., Alkan E. E., ZİREK A. K.

Brazilian Journal of Biology, vol.83, 2023 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 83
  • Publication Date: 2023
  • Doi Number: 10.1590/1519-6984.251198
  • Journal Name: Brazilian Journal of Biology
  • Journal Indexes: Scopus, Agricultural & Environmental Science Database, Animal Behavior Abstracts, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Keywords: Antioxidant activities, DNA damage, Gundelia tournefortii L, High-calorie diet, Obesity, Reactive oxygen species
  • Hakkari University Affiliated: Yes


The present study was designed to investigate the effects of Gundelia tournefortii L. plant extract on different tissues in terms of DNA damage, biochemical and antioxidant parameter values in rats with high-calorie diets. With this aim, Wistar albino male rats were divided into 4 groups containing 6 rats each and the study was completed over 12 weeks duration. At the end of the implementation process over the 12 weeks, rats were sacrificed and blood and tissue samples were obtained. Analyses were performed on blood and tissue samples. According to results for DNA damage (8-OHdG), in brain tissue the OG2 group was significantly reduced compared to the NC group. For MDA results in liver tissue, OG1 and OG2 groups were determined to increase by a significant degree compared to the control group, while the OG2 group was also increased significantly compared to the obese group. In terms of the other parameters, comparison between the groups linked to consumption of a high calorie diet (HCD) and administration of Gundelia tournefortii L. in terms of antioxidant activities and serum samples obtained statistically significant results. Gundelia tournefortii L. plant extracts had effects that may be counted as positive on antioxidant parameter activity and were especially identified to improve DNA damage and MDA levels in brain tissues. Additionally, consumption of Gundelia tournefortii L. plant extract in the diet may have antiobesity effects; thus, it should be evaluated for use as an effective weight-loss method and as a new therapeutic agent targeting obesity.