Lewis acid catalyzed (3 + 2)-annulations of donor-acceptor cyclopropanes and ynamides

Mackay W. D., Fistikci M., Carris R. M., Johnson J. S.

Organic Letters, cilt.16, sa.6, ss.1626-1629, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 6
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1021/ol500256n
  • Dergi Adı: Organic Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1626-1629
  • Hakkari Üniversitesi Adresli: Hayır

Özet

The Sc(OTf)3-catalyzed (3 + 2)-annulation of donor-acceptor cyclopropanes and ynamides is described, providing the corresponding cyclopentene sulfonamides in good to excellent yield. Deprotection and hydrolysis of the resulting ensulfonamides delivers 2,3-substituted cyclopentanones with high diastereoselectivity. © 2014 American Chemical Society.