Bromination of quinoxaline and derivatives: Effective synthesis of some new brominated quinoxalines

UÇAR S., Eşsiz S., DAŞTAN A.

Tetrahedron, vol.73, no.12, pp.1618-1632, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 12
  • Publication Date: 2017
  • Doi Number: 10.1016/j.tet.2017.02.014
  • Journal Name: Tetrahedron
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1618-1632
  • Keywords: Aromatization, Birch reduction, Bromination, Quinoxaline, Tetrahydroquinoxaline
  • Hakkari University Affiliated: Yes


The synthesis of brominated quinoxaline derivatives starting from several kinds of quinoxaline by different bromination strategies was studied. First the synthesis of some brominated quinoxalines was accomplished along with the development of an alternative and effective synthesis of some known compounds. A new, clean, and effective synthetic method for selective reduction of quinoxaline to 1,2,3,4-tetrahydroquinoxaline was also developed. The products obtained were characterized by means of NMR spectroscopy, elemental analyses, and mass spectrometry.